Blar i Bergen Open Research Archive på forfatter "Holen, Børge"

Viser treff 1-9 av 9

    • Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders 

      Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey; Parker, Nadine; O'Connell, Kevin Sean; Rødevand, Linn; Cheng, Weiqiu; Bahrami, Shahram; Karadag, Naz; Holen, Børge; Jaholkowski, Piotr Pawel; Woldeyohannes, Markos Tesfaye; Djurovic, Srdjan; Dale, Anders M.; Frei, Oleksandr; Ueland, Thor; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative ...

    • Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts 

      Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; O'Connell, Kevin Sean; Karthikeyan, Sandeep; Holen, Børge; Shadrin, Alexey; Rahman, Zillur; Karadag, Naz; Bahrami, Shahram; Lin, Aihua; Steen, Nils Eiel; Ueland, Thor; Aukrust, Pål; Djurovic, Srdjan; Dale, Anders; Smeland, Olav Bjerkehagen; Frei, Oleksandr; Andreassen, Ole (Journal article; Peer reviewed, 2024)
      Background For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This may be driven in part by shared genetic architecture. ...

    • Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression 

      Holen, Børge; Shadrin, Alexey; Icick, Romain; Filiz, Tahir Tekin; Hindley, Guy Frederick Lanyon; Rødevand, Linn; O'Connell, Kevin Sean; Hagen, Espen; Frei, Oleksandr; Bahrami, Shahram; Cheng, Weiqiu; Parker, Nadine; Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Karadag, Naz; Dale, Anders M; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Opioid use disorder (OUD) and mental disorders are often comorbid, with increased morbidity and mortality. The causes underlying this relationship are poorly understood. Although these conditions are highly heritable, their ...

    • Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci 

      Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos; Bahrami, Shahram; Nerhus, Mari; Rahman, Zillur; O'Connell, Kevin Sean; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; Rødevand, Linn; Karadag, Naz; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. We applied a ...

    • Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders 

      Karadag, Naz; Shadrin, Alexey; O'Connell, Kevin S; Hindley, Guy Frederick Lanyon; Rahman, Zillur; Parker, Nadine; Bahrami, Shahram; Fominykh, Vera; Cheng, Weiqiu; Holen, Børge; Alvestad, Silje; Taubøll, Erik; Steen, Nils Eiel; Djurovic, Srdjan; Dale, Anders M; Frei, Oleksandr; Andreassen, Ole; Smeland, Olav Bjerkehagen (Journal article; Peer reviewed, 2023)
      Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity and overlapping symptoms. However, the causative mechanisms underlying this relationship are poorly understood. Here we aimed to ...

    • Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia 

      O'Connell, Kevin Sean; Koch, Elise; Lenk, Hasan Cagin; Akkouh, Ibrahim Ahmed; Hindley, Guy Frederick Lanyon; Jaholkowski, Piotr Pawel; Smith, Robert Løvsletten; Holen, Børge; Shadrin, Alexey; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Dale, Anders M; Molden, Espen; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ...

    • Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis 

      Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Rahman, Zillur; Bahrami, Shahram; Lin, Aihua; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Rødevand, Linn; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; O’Connell, Kevin S.; Andreassen, Ole (Journal article; Peer reviewed, 2023-08-01)
      Background: Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of ...

    • Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood 

      Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Wang, Yunpeng; Shadrin, Alexey; Alnæs, Dag; Bahrami, Shahram; Lin, Aihua; Karadag, Naz; Holen, Børge; Fernández-Cabello, Sara; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Westlye, Lars Tjelta; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2022)
      Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ...

    • Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids 

      Osete, Jordi Requena; Akkouh, Ibrahim Ahmed; Levglevskyi, Oleksandr; Vandenberghe, Matthieu; Reis de Assis, Denis; Ueland, Thor; Kondratskaya, Elena; Holen, Børge; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2023)
      Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ...